Amlioration de la biodisponibilit de l'irbsartan par dispersion solide by Rashmi
$ 37.82
Description
Amlioration de la biodisponibilit de l'irbsartan par dispersion solide by Rashmi. Amlioration de la biodisponibilit de l'irbsartan par dispersion solide by Rashmitha Vallala, Shravan Kumar Yamsani, Srinivas Reddy Karka. Title Amlioration de la biodisponibilit de l'irbsartan par dispersion solide. Amlioration de la biodisponibilit de l'irbsartan par dispersion solide by Rashmitha Vallala, Shravan Kumar Yamsani, Srinivas Reddy Karka Estimated delivery 3-12 business days Format Paperback Condition Brand New Description L'hypertension est une affection prévalente, en particulier chez les personnes de plus de 50 ans, et peut entraîner des complications cardiovasculaires graves. L'irbésartan, un inhibiteur du récepteur de l'angiotensine II (ARA), est couramment utilisé pour gérer l'hypertension, mais sa faible solubilité aqueuse (1 μg/ml) limite sa biodisponibilité. Cette étude visait à améliorer la solubilité de l'Irbesartan par le biais de dispersions solides utilisant des supports tels que la β-cyclodextrine, HPMC K4M, PEG4000 et la gélatine. La β-cyclodextrine a montré la plus grande amélioration de la solubilité, comme le confirment les études de solubilité de phase. La caractérisation par DSC et SEM a indiqué la transformation du médicament de la forme cristalline à la forme amorphe, améliorant ainsi la dissolution. Les études FTIR ont confirmé l'absence d'interaction entre le médicament et les supports. Les tests de dissolution in vitro ont révélé que les formulations de β-cyclodextrine (1:9) augmentaient significativement le taux de dissolution par rapport à l'Irbesartan pur et aux autres supports. Ainsi, l'utilisation de la β-cyclodextrine dans les dispersions solides améliore efficacement la solubilité de l'Irbesartan et son potentiel thérapeutique dans le traitement de l'hypertension. Details ISBN 6208230659 ISBN-13 9786208230654 Title Amlioration de la biodisponibilit de l'irbsartan par dispersion solide Author Rashmitha Vallala, Shravan Kumar Yamsani, Srinivas Reddy Karka Format Paperback Year 2024 Pages 84 Publisher Editions Notre Savoir GEItemID:168667619; About Us Grand Eagle Retail is the ideal place for all your shopping needs! With fast shipping, low prices, friendly service and over 1,000,000 in stock items - you're bound to find what you want, at a price you'll love! Shipping & Delivery Times Shipping is FREE to any address in USA. Please view eBay estimated delivery times at the top of the listing. Deliveries are made by either USPS or Courier. We are unable to deliver faster than stated. International deliveries will take 1-6 weeks. NOTE: We are unable to offer combined shipping for multiple items purchased. This is because our items are shipped from different locations. Returns If you wish to return an item, please consult our Returns Policy as below: Please contact Customer Services and request "Return Authorisation" before you send your item back to us. Unauthorised returns will not be accepted. Returns must be postmarked within 4 business days of authorisation and must be in resellable condition. Returns are shipped at the customer's risk. We cannot take responsibility for items which are lost or damaged in transit. For purchases where a shipping charge was paid, there will be no refund of the original shipping charge. Additional Questions If you have any questions please feel free to Contact Us. Categories Baby Books Electronics Fashion Games Health & Beauty Home, Garden & Pets Movies Music Sports & Outdoors Toys
