Integrins and Ion Channels : Molecular Complexes and Signaling, Hardcover by ...
$ 114.83
Description
Integrins and Ion Channels : Molecular Complexes and Signaling, Hardcover by Becchetti, Andrea (EDT); Arcangeli, Annarosa (EDT), ISBN 1441960651, ISBN-13 9781441960658, Like New Used, Free shipping in the US Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In othercases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.
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As pictured / as described. Shipping - I ordered Dec 12 and glanced to see something like "Arrives ... 17th-21st", quickly thinking, "OK - plenty of time for Christmas". When it didn't show up, I went back to find it was actually "January 14th-17th" - oops! my goof! Wasn't expecting 5 week shipping. But ultimately, it did come in on Dec 26th, so quicker than the stated and might have been even quicker if not for holidays. Otherwise, good packing. Quick, easy transaction. Thanks!
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