Mechanism of Bone Destruction by Shivani Gupta Paperback Book
$ 40.67
Description
Mechanism of Bone Destruction by Shivani Gupta Paperback Book. Author Shivani Gupta, Prerna Agarwal, Ashutosh Agarwal. It results from an imbalance between bone resorption by osteoclasts and formation by osteoblasts. Osteoclast activity is regulated by the RANK/RANKL/OPG axis, where an increased RANKL/OPG ratio promotes osteoclastogenesis. Mechanism of Bone Destruction by Shivani Gupta, Prerna Agarwal, Ashutosh Agarwal Estimated delivery 3-12 business days Format Paperback Condition Brand New Description Bone destruction is central to conditions like osteoporosis, rheumatoid arthritis, and cancers with bone metastases. It results from an imbalance between bone resorption by osteoclasts and formation by osteoblasts. Osteoclast activity is regulated by the RANK/RANKL/OPG axis, where an increased RANKL/OPG ratio promotes osteoclastogenesis. Inflammatory cytokines (e.g., TNF-α, IL-1, IL-6) enhance RANKL expression and osteoclast survival. In cancer, tumor-derived factors like PTHrP and prostaglandins further drive RANKL-mediated bone loss. Bone resorption releases growth factors such as TGF-β, fueling tumor growth and perpetuating degradation. Enzymes like MMPs and cathepsin K degrade bone matrix, while hypoxia and mechanical stress also contribute. Understanding these mechanisms supports treatments like bisphosphonates, RANKL inhibitors (e.g., denosumab), and anti-cytokine therapies, which effectively reduce bone loss. Details ISBN 620844523X ISBN-13 9786208445232 Title Mechanism of Bone Destruction Author Shivani Gupta, Prerna Agarwal, Ashutosh Agarwal Format Paperback Year 2025 Pages 88 Publisher LAP Lambert Academic Publishing GEItemID:173062646; About Us Grand Eagle Retail is the ideal place for all your shopping needs! With fast shipping, low prices, friendly service and over 1,000,000 in stock items - you're bound to find what you want, at a price you'll love! Shipping & Delivery Times Shipping is FREE to any address in USA. Please view eBay estimated delivery times at the top of the listing. Deliveries are made by either USPS or Courier. We are unable to deliver faster than stated. International deliveries will take 1-6 weeks. NOTE: We are unable to offer combined shipping for multiple items purchased. This is because our items are shipped from different locations. Returns If you wish to return an item, please consult our Returns Policy as below: Please contact Customer Services and request "Return Authorisation" before you send your item back to us. Unauthorised returns will not be accepted. Returns must be postmarked within 4 business days of authorisation and must be in resellable condition. Returns are shipped at the customer's risk. We cannot take responsibility for items which are lost or damaged in transit. For purchases where a shipping charge was paid, there will be no refund of the original shipping charge. Additional Questions If you have any questions please feel free to Contact Us. Categories Baby Books Electronics Fashion Games Health & Beauty Home, Garden & Pets Movies Music Sports & Outdoors Toys
